In San Francisco, Jill Valentine is dealing with a zombie outbreak and a new T-Virus, Leon Kennedy is on the trail of a kidnapped DARPA scientist, and Claire Redfield is investigating a monstrous fish that is killing whales in the bay. Joined by Chris Redfield and Rebecca Chambers, they discover the trail of clues from their separate cases all converge on the same location, Alcatraz Island, where a new evil has taken residence and awaits their arrival.
The story takes place in the infamous prison on Alcatraz Island, where we’ll follow two separate storylines involving Leon Kennedy and Chris Redfield. Leon is hot on the trail of some bad guys who’ve abducted a scientist with classified information that could put millions at risk. Unfortunately, his pursuit is sidetracked by a mysterious woman who appears out of nowhere. Meanwhile, Chris Redfield is tasked with investigating a mysterious infection that’s taken hold of San Francisco. As he digs deeper, he realizes that all the victims had visited one particular place – Alcatraz prison.
When Chris and his team board a ferry to head to the island, they have no idea what they’re in for. Alcatraz is about to become “Death Island” for them.